ABSTRACT
Essential thrombocythemia is an increase of the initial platelet, which frequency tends to increase with the generalization of platelet counts on automat, allowing a positive diagnosis. The objective of this study is to compare platelet parameters of the ADVIA 120@ [Bayer Diagnostic, Tarrytown USA] between two populations of essential thrombocythemia [ET] and Secondary Thrombocythemia [ST] and to establish threshold values for these analyzed platelet parameters. This study include 210 patients, hospitalized at service of internal medicine, and whose selection criteria were an platelet count > 400G/L and/or diagnosis of Essential thrombocythemia. Then, the formula composed with threshold values of platelet parameters that we have found was applied on other groups of patients with a hyper-platelet count >400G/L and whose diagnosis was undetermined. Six platelet parameters out of nine present a significant difference between Et and ST [Mean platelet volume [VPM], variation Coefficient of the platelet of the platelet volume [CV Plat], Mean Platelet, Concentration [CPM], Standard deviation of the platelet concentration [ETCP], big platelet and Aggregate count], and the combination of at least four parameters, gives a sensitive [65 percent] and specific [95 percent] diagnosis Key for ET. These preliminary results show a major interest for ETCP parameters and big platelet parameters. Their association with other platelet parameters and the platelet count higher than 600 G/L should allow to better direct the diagnosis of ET